Will move for approval in US and Europe later this year
Eagerly awaited Phase 3 trial results were released early Tuesday morning from Intercept Pharmaceuticals, showing positive results for the study’s primary goal of showing a statistically significant reduction in liver fibrosis compared to placebo. As a result, Intercept will seek approval in the US and Europe to permit the drug, known as Ocaliva, to be used as the first ever treatment for NASH-related fibrosis. The stock price rose as high as 23% on the news.
Continue reading “Intercept Pharma announces successful Phase 3 NASH trials”
I’ve written before about how weight management might be a lot more about what is happening in your gut than whatever diet of the month you are trying. This is one reason why bariatric surgery may be the most effective long-term weight loss solution available; it changes and restores the makeup of gut microbiota.
New research released at the end of 2018 is taking this understanding of microbiota even further, finding strong ties with a specific bacteria called Akkermansia muciniphila not only to obesity but also increased insulin resistance and other effects of aging when looking at how specific types of gut bacteria change over time. Continue reading “More evidence of gut bacteria’s involvement in obesity and insulin resistance”
One of the most difficult challenges with NASH is that it is so difficult to diagnose. While many Biotech companies are working hard to develop a cure for NASH, some are also busy developing new innovative methods to detect NASH without requiring an invasive liver biopsy.
Genfit is one of the few companies due to release Phase 3 trials of NASH treatments in 2019. Not content with focusing merely on a cure, they are also nearing completion of trials on a new blood test for earlier detection of NASH. They have just recently announced a partnership with LabCorp, which will allow them access to a much wider audience for the clinical research required to validate the new test.
Continue reading “Genfit and LabCorp team up to develop NASH diagnostic tests”
A new study from New York Presbyterian Hospital has some eyebrow-raising findings. We already know that drinking coffee is good for the liver, but you would expect to find less evidence of a positive relationship with alcohol. Yes, there have been plenty of studies that show a glass of wine can be good for you, but never one that highlighted an actual positive link.
This study goes even further and finds that moderate drinking can actually lead to a reduced mortality risk in patients with NAFLD. Wut??? Continue reading “Modest alcohol consumption may REDUCE mortality in patients with NAFLD”
It’s another promising result from one of the dozens of bio-pharmaceutical companies trying to find treatments for fatty liver disease. Viking Therapeutics announced results from an early study of NAFLD patients that exceeded expectations yesterday, sending the stock soaring 122%.
Continue reading “Viking Therapeutics delivers promising results in NALFD trial”
Yesterday the CDC released their 2017 Obesity data for the United States, and the data is not very encouraging. Seven states reported obesity rates at or above 35%!
Continue reading “CDC releases new Obesity map for the USA”
I lost my mother suddenly to late-stage NASH when she was only 62 years old. The search for answers and meaning has led me to working with the American Liver Foundation and starting this blog. One thing that has become increasingly clear to me was that my mom’s decades of hypothyroidism could have been a major cause of her progression to NASH. Now, a new meta-study examining 18 years of data has concluded that those patients with primary hypothyroidism are at a 42% increased risk for developing NAFLD, the precursor to NASH. Continue reading “The Thyroid’s link to NASH”